DHS “R” mediates retinoic acid-induced OTX2 repression.
- Matthew Wortham (155847)
- Changcun Guo (224423)
- Monica Zhang (627070)
- Lingyun Song (143959)
- Bum-Kyu Lee (155859)
- Vishwanath R. Iyer (50525)
- Terrence S. Furey (136444)
- Gregory E. Crawford (143971)
- Hai Yan (168017)
- Yiping He (168012)
Publication date
September 2014
DOIAbstract
<p>(A) DNase sensitivity of DHS “R” in three OTX2-expressing (D283, D341, D721) and two OTX2-nonexpressing (D324, UW228) medulloblastoma cell lines. (B) Luciferase assays measuring enhancer activity of DHS “R” following treatment with 2 µM all-<i>trans</i> retinoic acid (ATRA) for 24 hours. (C) OTX2 mRNA level as determined by qPCR of medulloblastoma cells treated with 2 µM all-<i>trans</i> retinoic acid (ATRA) and/or 35 µM cycloheximide (CYHEX) for 8 hours. *<i>p</i><0.05 relative to DMSO, **<i>p</i><0.01 relative to DMSO, Student's t-test. Error bars indicate standard deviation.</p
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